研究開発・学会発表

10月のおはな

Fertility and Sterility

学会名

Fertility and Sterility

日・場所

vol.83, No.3,March 2005 (平成17年3月)

タイトル

Effectiveness of two-step (consecutive) embryo transfer in patients who have two embryos on day 2: comparison with cleavage-stage embryo transfer

発表者名

Sakae GotoM.D., Ph.D., Masahide Shiotani M.D., Ph.D., Masaru KitagawaM.D., Ph.D.,
( Hanabusa Women's Clinic, Kobe, Japan.)
Takashi Kadowaki M.D., M.P.H., Ph.D.,
(Department of Obstetrics and Gynecology, Shiga University of Medical Science, Otsu, Japan.)
and Yoichi NodaM.D., Ph.D.
(Department of Health Science, Shiga University of Medical Science, Otsu, Japan. )

【要旨】

Objective: To Evaluate the effectiveness, for patients who have only two embryos on day 2, of a two-step (consecutive) embryo transfer (ET) procedure in which a cleaved embryo is transferred on day 2 and a single blastocyst is transferred on day 5.
Design: Observational comparative study.
Setting: Private IVF clinic.
Patient(s): Ninety two-step ET cycles were performed in patients who had 2 embryos on day 2 (two-step group). Ninety day-2 ET cycles were performed in age- and infertility-matched patients who had 2 embryos on day 2 (control group).
Intervention(s): Cleaved-embryo transfer, extended culture of one embryo, and a second transfer of a blastocyst.
Main Outcome Measure(s): Implantation and pregnancy rates.
Result(s): The pregnancy and implantation rates in the two-step group (respectively 33.3% and 17.2%) were significantly higher than those in the control group (18.9 % and 9.4%). Thirty-nine of the patients in the two-step group (43.3%) could not proceed to the second step of ET because no viable blastocyst could be obtained, but four of them conceived anyway.
Conclusion: Taking advantage of both day-2 ET and blastocyst transfer, two-step ET may be an effective option for embryo transfer in patients who have an insufficient number of embryos.
Key words: Two-step embryo transfer, blastocyst, poor responder