研究開発・学会発表
診療・治療
Is PGT-A effective even with only a few blastocycts available for boppsy?
- 第70回 日本人類遺伝学会
- 2025/12/17～12/20 パシフィコ横浜
- Is PGT-A effective even with only a few blastocycts available for boppsy?
- Eri Nakahara1)、Shoji Kokeguchi1)、Eri Okamoto1)、Yihsien Enatsu1)、Chinatsu Kinjyo1)2)、Shibahara Hiroaki1), Masahide Shiotani1)
1) Hanabusa Women’s Clinic 2) Hyogo Medical University Hospital
Background and Objective: In Japan, Preimplantation Genetic Testing for Aneuploidy (PGT-A) is performed under limited criteria not always based on strong evidence. Some argue PGT-A should not be done when few blastocysts (BLs) are available. This study aimed to evaluate PGT-A effectiveness by focusing on the number of BLs biopsied per oocyte retrieval (OR).
Materials and Methods: We retrospectively analyzed 484 OR cycles scheduled for PGT-A at our clinic from May 2020 to April 2025. The average age was 41.1 ± 2.76 years. We examined embryo transfer (ET) rate, clinical pregnancy rate, miscarriage rate, and ongoing pregnancy rate by the number of biopsied BLs. We also compared clinical outcomes between PGT-A and non-PGT-A groups with only one BL frozen at age 41. Chi-square tests were used.
Results: No significant age differences were found among groups biopsying one, two, or three BLs. ET rates were 19.0%, 28.0%, and 36.7%. Clinical pregnancy rates were 8.3%, 18.7%, and 32.7%; miscarriage rates 0.0%, 2.7%, and 6.1%; ongoing pregnancy rates 8.3%, 16.0%, and 24.5%. Outcomes improved with more biopsied BLs. Comparing PGT-A vs. non-PGT-A, clinical pregnancy rates were 8.3% vs. 20.1% (p<0.01), miscarriage rates 0.0% vs. 8.8% (p<0.001), ongoing pregnancy rates showed no significant difference.
Conclusion: Pregnancy outcomes improved with more biopsied embryos at the same age, suggesting culture results should be considered in PGT-A indications. Even one biopsied BL may help avoid miscarriage burden. Criteria should balance clinical outcomes and patient needs.
